The Multifaceted Role of miR-18b in Cancer: Exploring Oncogenic and Tumor-Suppressive Functions
DOI:
https://doi.org/10.62382/jcbt.v1i1.12Keywords:
miR-18b, Cancer, Oncogene, Tumor suppressor, BiomarkerAbstract
Cancer continues to pose a major global health challenge due to its high mortality rates and increasing incidence. MicroRNAs (miRNAs), which are small non-coding RNAs regulating gene expression at the post-transcriptional level, are pivotal in the development of cancer, serving either as oncogenes or tumor suppressors. miR-18b has become involved in a number of cancers and has been shown to perform both tumor-suppressive and carcinogenic activities. This review examines the biogenesis, molecular mechanisms, and functional roles of miR-18b across several cancers, including breast cancer, lung cancer, colorectal cancer, gastric cancer, and other malignancies. Treatment resistance, metastasis, and the advancement of cancer are all influenced by miR-18b through its regulation of vital pathways and interactions with circular and long non-coding RNAs. These findings emphasize the importance of miR-18b in developing cancer treatment approaches by highlighting its possible roles as a therapeutic target and diagnostic biomarker.
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