Emerging Roles of tsRNAs: Novel Biomarkers and Therapeutic Targets in Gynecological Oncology
DOI:
https://doi.org/10.62382/jcbt.v2i1.43Keywords:
tsRNAs (transfer RNA-derived small RNAs), gynecological cancers, gene regulation, diagnostic biomarkers, RNA-based therapiesAbstract
Transfer RNA-derived small RNA (tsRNAs) are a diverse group of non-coding RNAs that play key roles in controlling gene expression and the body's response to stress. Recent studies indicate that tsRNAs are not only byproducts of tRNA breakdown; rather, they actively participate in different biological processes, including tumor development. In gynecological cancers, including ovarian, cervical, and endometrial cancers, tsRNAs have been associated with the modulation of essential cancer-related pathways, affecting cell proliferation, migration, and apoptosis. This review examines the biosynthesis, categorization, and functional importance of tsRNAs, particularly regarding their role in gynecological cancers. The anomalous expression of tsRNAs in these malignancies underscores their potential as diagnostic tools and therapeutic targets. The increasing data supporting RNA-based methods for cancer diagnosis and therapy highlights the significance of tsRNAs as potential candidates for novel therapeutics in gynecological cancers.
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